Jump to main content
Jump to site search

Issue 4, 2012
Previous Article Next Article

Squaric acid: a valuable scaffold for developing antimalarials?

Author affiliations

Abstract

We describe here the synthesis of a library of thirty-eight squaric derivatives and the evaluation of activity against papain-, falcipain-2- and a chloroquine-resistant strain of P. falciparum. The most active compounds combine significant antiplasmodial activity with minimal cytotoxicity.

Graphical abstract: Squaric acid: a valuable scaffold for developing antimalarials?

Back to tab navigation

Supplementary files

Publication details

The article was received on 19 Jan 2012, accepted on 05 Feb 2012 and first published on 08 Feb 2012


Article type: Concise Article
DOI: 10.1039/C2MD20011B
Med. Chem. Commun., 2012,3, 489-493

  •   Request permissions

    Squaric acid: a valuable scaffold for developing antimalarials?

    S. P. Kumar, P. M. C. Glória, L. M. Gonçalves, J. Gut, P. J. Rosenthal, R. Moreira and M. M. M. Santos, Med. Chem. Commun., 2012, 3, 489
    DOI: 10.1039/C2MD20011B

Search articles by author

Spotlight

Advertisements