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Issue 4, 2012
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A second generation MRI contrast agent for imaging zinc ions in vivo

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Abstract

A Zn2+ specific GdDOTA derivative containing two bis-(3-pyrazolyl) units was prepared and characterized. Unlike a previously reported Zn2+ binding agent, the new agent binds to human albumin both in the presence and absence of Zn2+.

Graphical abstract: A second generation MRI contrast agent for imaging zinc ions in vivo

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Publication details

The article was received on 06 Dec 2011, accepted on 23 Jan 2012 and first published on 07 Mar 2012


Article type: Concise Article
DOI: 10.1039/C2MD00301E
Med. Chem. Commun., 2012,3, 480-483

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    A second generation MRI contrast agent for imaging zinc ions in vivo

    L. M. De León-Rodríguez, A. J. M. Lubag, J. A. López, G. Andreu-de-Riquer, J. C. Alvarado-Monzón and A. D. Sherry, Med. Chem. Commun., 2012, 3, 480
    DOI: 10.1039/C2MD00301E

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