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Issue 3, 2012
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Antimalarial peroxides: advances in drug discovery and design

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Abstract

Cyclic peroxides such as the plant-derived 1,2,4-trioxane artemisinin and its derivatives are short-lived, rapidly-acting antimalarials that are now usually combined with standard long-lived, alkaloidal antimalarials; such artemisinin combination therapy (ACT) is the worldwide standard operating procedure for malaria chemotherapy. This review discusses antimalarial monomeric and dimeric derivatives of artemisinin, peroxides not derived from artemisinin, and finally hybrids containing one peroxide unit covalently linked to a non-peroxide unit. Emphasis is placed on the antimalarial effectiveness of these diverse cyclic peroxides and on the simplicity of their synthesis.

Graphical abstract: Antimalarial peroxides: advances in drug discovery and design

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Publication details

The article was received on 02 Nov 2011, accepted on 06 Dec 2011 and first published on 07 Dec 2011


Article type: Review Article
DOI: 10.1039/C2MD00277A
Med. Chem. Commun., 2012,3, 281-297

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    Antimalarial peroxides: advances in drug discovery and design

    R. D. Slack, A. M. Jacobine and G. H. Posner, Med. Chem. Commun., 2012, 3, 281
    DOI: 10.1039/C2MD00277A

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