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Issue 4, 2012
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Development of novel ionic liquids based on ampicillin

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Novel ionic liquids containing ampicillin as an active pharmaceutical ingredient anion were prepared with good yields by using a new, efficient synthetic procedure based on the neutralization of a moderately basic ammonia solution of ampicillin with different organic cation hydroxides. The relevant physical and thermal properties of these novel ionic liquids based on ampicillin were also evaluated.

Graphical abstract: Development of novel ionic liquids based on ampicillin

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The article was received on 24 Oct 2011, accepted on 13 Feb 2012 and first published on 15 Feb 2012

Article type: Concise Article
DOI: 10.1039/C2MD00269H
Med. Chem. Commun., 2012,3, 494-497

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    Development of novel ionic liquids based on ampicillin

    R. Ferraz, L. C. Branco, I. M. Marrucho, J. M. M. Araújo, L. P. N. Rebelo, M. N. da Ponte, C. Prudêncio, J. P. Noronha and Ž. Petrovski, Med. Chem. Commun., 2012, 3, 494
    DOI: 10.1039/C2MD00269H

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