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Issue 4, 2012
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A solid-phase method for peptide–siRNA covalent conjugates based on click chemistry

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Abstract

In order to prepare a new delivery system by chemical modification, peptide–siRNA conjugates have been obtained by a solid-phase click chemistry strategy, using an alkynyl nucleoside analogue “clicked” onto a peptide-derivatized CPG (Controlled Pore Glass) followed by oligonucleotides synthesis. The 3′-sense strand conjugate maintained good gene silencing activity, while that of the 3′-antisense strand conjugate decreased somewhat.

Graphical abstract: A solid-phase method for peptide–siRNA covalent conjugates based on click chemistry

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Publication details

The article was received on 01 Aug 2011, accepted on 23 Jan 2012 and first published on 29 Feb 2012


Article type: Concise Article
DOI: 10.1039/C2MD00198E
Med. Chem. Commun., 2012,3, 506-511

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    A solid-phase method for peptide–siRNA covalent conjugates based on click chemistry

    Y. Liu, X. Wang, Y. Chen, L. Zhang and Z. Yang, Med. Chem. Commun., 2012, 3, 506
    DOI: 10.1039/C2MD00198E

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