Issue 2, 2012
From the journal:

MedChemComm

A concise synthesis of the potent inflammatory mediator 5-oxo-ETE†

Rahul Tyagi,a   Bharat Shimpukade,a   Stefanie Blättermann,b   Evi Kostenisb  and  Trond Ulven*a  

* Corresponding authors

a Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, Odense M, Denmark
E-mail: ulven@ifk.sdu.dk
Fax: +45 6615 8780
Tel: +45 6550 2568

b Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, Bonn, Germany

Abstract

A concise and practical method for synthesis of the potent inflammatory mediator 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-oxo-ETE, 1) from arachidonic acid in four steps and 70% overall yield is reported. Stability studies indicate that 1 can be safely handled without rigorous precautions.

Graphical abstract: A concise synthesis of the potent inflammatory mediator 5-oxo-ETE

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Article information

DOI
https://doi.org/10.1039/C1MD00231G
Article type
Concise Article
Submitted
09 Sep 2011
Accepted
26 Sep 2011
First published
20 Oct 2011

Med. Chem. Commun., 2012,3, 195-198

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A concise synthesis of the potent inflammatory mediator 5-oxo-ETE

R. Tyagi, B. Shimpukade, S. Blättermann, E. Kostenis and T. Ulven, Med. Chem. Commun., 2012, 3, 195 DOI: 10.1039/C1MD00231G

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