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Issue 12, 2012
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Activation of monocytic cells by immunostimulatory lipids conjugated to peptide antigens

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Abstract

Bacterial derived lipoproteins constitute potent macrophage activators in vivo and are effective stimuli, enhancing the immune response especially with respect to low or non-immunogenic compounds. In the present study we have prepared branched lipopeptide constructs in which different (B- and T-cell) epitopes of Herpes simplex virus type 1, derived from glycoproteins B (gB) and D (gD), are linked to a synthetic lipid core. The ability of the lipid core peptide (LCP) constructs (LCP-gB and LCP-gD) to induce cytokine expression and activate the mitogen-activated protein kinase cascade has been evaluated and compared with the behaviour of the isolated epitopes and the lipid core. In this respect, the use of LCP technology coupled with the use of three different gB or gD peptide epitopes in the same branched constructs could represent an interesting approach in order to obtain efficient delivery systems in the development of a synthetic multiepitopic vaccine for the prevention of viral infections.

Graphical abstract: Activation of monocytic cells by immunostimulatory lipids conjugated to peptide antigens

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Supplementary files

Article information


Submitted
30 Sep 2011
Accepted
03 May 2012
First published
10 May 2012

Mol. BioSyst., 2012,8, 3166-3177
Article type
Paper

Activation of monocytic cells by immunostimulatory lipids conjugated to peptide antigens

S. Galdiero, M. Vitiello, E. Finamore, R. Mansi, M. Galdiero, G. Morelli and D. Tesauro, Mol. BioSyst., 2012, 8, 3166
DOI: 10.1039/C2MB25064K

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