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Issue 20, 2012
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Semi-autonomous liquid handling via on-chip pneumatic digital logic

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Abstract

This report presents a liquid-handling chip capable of executing metering, mixing, incubation, and wash procedures largely under the control of on-board pneumatic circuitry. The only required inputs are four static selection lines to choose between the four machine states, and one additional line for power. State selection is simple: constant application of vacuum to an input causes the device to execute one of its four liquid handling operations. Programmed control of 31 valves, including fast coordinated cycling for peristaltic pumping, is accomplished by pneumatic digital logic circuits built out of microfluidic valves and channels rather than electronics, eliminating the need for the off-chip control machinery that is typically required for integrated microfluidics.

Graphical abstract: Semi-autonomous liquid handling via on-chip pneumatic digital logic

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Supplementary files

Article information


Submitted
30 Apr 2012
Accepted
23 Aug 2012
First published
11 Sep 2012

Lab Chip, 2012,12, 3991-3994
Article type
Paper

Semi-autonomous liquid handling via on-chip pneumatic digital logic

T. V. Nguyen, P. N. Duncan, S. Ahrar and E. E. Hui, Lab Chip, 2012, 12, 3991
DOI: 10.1039/C2LC40466D

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