Jump to main content
Jump to site search

Issue 12, 2012
Previous Article Next Article

Droplet microfluidics for high-throughput biological assays

Author affiliations


Droplet microfluidics offers significant advantages for performing high-throughput screens and sensitive assays. Droplets allow sample volumes to be significantly reduced, leading to concomitant reductions in cost. Manipulation and measurement at kilohertz speeds enable up to 108 samples to be screened in one day. Compartmentalization in droplets increases assay sensitivity by increasing the effective concentration of rare species and decreasing the time required to reach detection thresholds. Droplet microfluidics combines these powerful features to enable currently inaccessible high-throughput screening applications, including single-cell and single-molecule assays.

Graphical abstract: Droplet microfluidics for high-throughput biological assays

  • This article is part of the themed collection: Focus on USA
Back to tab navigation

Publication details

The article was received on 22 Nov 2011, accepted on 11 Jan 2012 and first published on 09 Feb 2012

Article type: Critical Review
DOI: 10.1039/C2LC21147E
Lab Chip, 2012,12, 2146-2155

  •   Request permissions

    Droplet microfluidics for high-throughput biological assays

    M. T. Guo, A. Rotem, J. A. Heyman and D. A. Weitz, Lab Chip, 2012, 12, 2146
    DOI: 10.1039/C2LC21147E

Search articles by author