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Issue 21, 2012
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Configuration change of liquid crystal microdroplets coated with a novel polyacrylic acid block liquid crystalline polymer by protein adsorption

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Abstract

4-cyano-4′-pentylbiphenyl (5CB) microdroplets coated with PAA-b-LCP were successfully made via microfluidics. Their functionalized interfaces were examined for lysozyme and bovine serum albumin detection, which could be easily visualized with an optical microscope under crossed polarizers by the radial-to-bipolar configurational change of the 5CB. This transition was strongly dependent on the electrostatic states of the proteins and PAA chains, which were controlled by the pH of the water. This study demonstrated a simple approach for the development of a liquid crystal-based sensor for label-free detection of proteins, which may have diverse applications in various biomedical fields.

Graphical abstract: Configuration change of liquid crystal microdroplets coated with a novel polyacrylic acid block liquid crystalline polymer by protein adsorption

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Publication details

The article was received on 09 Feb 2012, accepted on 07 Aug 2012 and first published on 08 Aug 2012


Article type: Paper
DOI: 10.1039/C2LC40710H
Lab Chip, 2012,12, 4553-4559

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    Configuration change of liquid crystal microdroplets coated with a novel polyacrylic acid block liquid crystalline polymer by protein adsorption

    W. Khan and S. Park, Lab Chip, 2012, 12, 4553
    DOI: 10.1039/C2LC40710H

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