Jump to main content
Jump to site search

Issue 15, 2012
Previous Article Next Article

Engineering and analysis of surface interactions in a microfluidic herringbone micromixer

Author affiliations

Abstract

We developed a computational model and theoretical framework to investigate the geometrical optimization of particle-surface interactions in a herringbone micromixer. The enhancement of biomolecule- and particle-surface interactions in microfluidic devices through mixing and streamline disruption holds promise for a variety of applications. This analysis provides guidelines for optimizing the frequency and specific location of surface interactions based on the flow pattern and relative hydraulic resistance between a groove and the effective channel. The channel bottom, i.e., channel surface between grooves, was identified as the dominant location for surface contact. In addition, geometries that decrease the groove-to-channel hydraulic resistance improve contact with the channel top. Thus, herringbone mixers appear useful for a variety of surface-interaction applications, yet they have largely not been employed in an optimized fashion.

Graphical abstract: Engineering and analysis of surface interactions in a microfluidic herringbone micromixer

Back to tab navigation

Supplementary files

Publication details

The article was received on 13 Apr 2012, accepted on 16 May 2012 and first published on 18 May 2012


Article type: Technical Innovation
DOI: 10.1039/C2LC40356K
Lab Chip, 2012,12, 2634-2637

  •   Request permissions

    Engineering and analysis of surface interactions in a microfluidic herringbone micromixer

    T. P. Forbes and J. G. Kralj, Lab Chip, 2012, 12, 2634
    DOI: 10.1039/C2LC40356K

Search articles by author

Spotlight

Advertisements