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Issue 10, 2012
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Microfluidic approaches for cancer cell detection, characterization, and separation

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Abstract

This article reviews the recent developments in microfluidic technologies for in vitro cancer diagnosis. We summarize the working principles and experimental results of key microfluidic platforms for cancer cell detection, characterization, and separation based on cell-affinity micro-chromatography, magnetic activated micro-sorting, and cellular biophysics (e.g., cell size and mechanical and electrical properties). We examine the advantages and limitations of each technique and discuss future research opportunities for improving device throughput and purity, and for enabling on-chip analysis of captured cancer cells.

Graphical abstract: Microfluidic approaches for cancer cell detection, characterization, and separation

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Article information


Submitted
21 Dec 2011
Accepted
10 Feb 2012
First published
15 Feb 2012

Lab Chip, 2012,12, 1753-1767
Article type
Critical Review

Microfluidic approaches for cancer cell detection, characterization, and separation

J. Chen, J. Li and Y. Sun, Lab Chip, 2012, 12, 1753
DOI: 10.1039/C2LC21273K

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