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Issue 39, 2012
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Temperature-responsive porous polycaprolactone-based films via surface-initiated ATRP for protein delivery

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Abstract

The inherent hydroxyl groups on the porous polycaprolactone (PPCL) films (prepared by using poly(ethylene glycol) as the pore-forming agent) could be reacted with 2-bromoisobutyrate bromide to produce a sufficient concentration of surface-coupled atom transfer radical polymerization (ATRP) initiators for the subsequent surface-initiated ATRP of thermo-responsive N-isopropylacrylamide (NIPAAm) at room temperature. A kinetics study revealed that the chain growth of the grafted NIPAAm polymer (P(NIPAAm)) was very fast and consistent with a ‘controlled’ process. The graft copolymerization not only occurred on the porous film surface, but also took place into the film bulk. The resultant P(NIPAAm)-grafted PPCL (PPCL-g-P(NIPAAm)) films assumed a uniform and interconnected porous structure and exhibited a temperature-sensitive property with a lower critical solution temperature (LCST) of about 32 °C, not unlike pure P(NIPAAm). The release of bovine serum albumin (BSA as a model protein) from the PPCL-g-P(NIPAAm) films was characterized by an initial burst, followed by a sustained release. These thermo-responsive PPCL-g-P(NIPAAm) porous films are potentially useful in biomedical fields.

Graphical abstract: Temperature-responsive porous polycaprolactone-based films via surface-initiated ATRP for protein delivery

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Article information


Submitted
25 Jul 2012
Accepted
24 Aug 2012
First published
28 Aug 2012

J. Mater. Chem., 2012,22, 21257-21264
Article type
Paper

Temperature-responsive porous polycaprolactone-based films via surface-initiated ATRP for protein delivery

Y. Hu, N. N. Zhao, J. S. Li, W. T. Yang and F. J. Xu, J. Mater. Chem., 2012, 22, 21257
DOI: 10.1039/C2JM34919A

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