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Issue 29, 2012
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Bioinspired synthesis of gadolinium-based hybrid nanoparticles as MRI blood pool contrast agents with high relaxivity

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Abstract

A unique biomineralization approach was developed to synthesize gadolinium-based hybrid (GH) nanoparticles for effective blood pool contrast agents. This approach is bioinspired, environmentally benign, and straightforward. As-prepared GH nanoparticles are biocompatible and well stable in serum. They exhibit much higher longitudinal relaxivity and transverse relaxivity in water (r1 and r2 values of 15.0 and 19.7 s−1 per mM of Gd3+, respectively) than those measured for Gd–DTPA solution (r1 and r2 values of 3.7 and 4.6 s−1 per mM of Gd3+, respectively). In vivo T1-weighted magnetic resonance imaging (MRI) in living mice shows that the GH nanoparticles have an intravascular half-life up to 1 h, much longer than that of Gd–DTPA (about 10 min). As the GH nanoparticles were found to be cleared gradually via hepatobiliary (HB) processing, they can also serve as ideal candidates for liver specific MR contrast agents. In particular, these GH nanoparticles are bioinspired and environmentally benign, therefore promising for medical imaging applications.

Graphical abstract: Bioinspired synthesis of gadolinium-based hybrid nanoparticles as MRI blood pool contrast agents with high relaxivity

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Publication details

The article was received on 01 Feb 2012, accepted on 21 May 2012 and first published on 24 May 2012


Article type: Paper
DOI: 10.1039/C2JM30629H
J. Mater. Chem., 2012,22, 14494-14501

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    Bioinspired synthesis of gadolinium-based hybrid nanoparticles as MRI blood pool contrast agents with high relaxivity

    B. Zhang, H. Jin, Y. Li, B. Chen, S. Liu and D. Shi, J. Mater. Chem., 2012, 22, 14494
    DOI: 10.1039/C2JM30629H

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