Issue 7, 2012

“On water” direct Pd-catalysed C–H arylation of thiazolo[5,4-d]pyrimidine derivatives

Abstract

A novel protocol for the direct arylation of thiazolo[5,4-d]pyrimidine derivatives with aryl iodides is reported. The reactions were catalysed by a combination of Pd(PPh3)4 and Ag2CO3 (acting as the oxidant and the base as well), using exclusively water as the solvent and furnishing the desired products in good to excellent yields at only 60 °C.

Graphical abstract: “On water” direct Pd-catalysed C–H arylation of thiazolo[5,4-d]pyrimidine derivatives

Supplementary files

Article information

Article type
Paper
Submitted
19 Mar 2012
Accepted
26 Apr 2012
First published
26 Apr 2012

Green Chem., 2012,14, 1979-1981

“On water” direct Pd-catalysed C–H arylation of thiazolo[5,4-d]pyrimidine derivatives

Y. Su, Y. Deng, T. Ma, Y. Li and L. Sun, Green Chem., 2012, 14, 1979 DOI: 10.1039/C2GC35399G

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