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Issue 10, 2012
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Copper(II) catalysis provides cyclohexanone-derived propargylamines free of solvent or excess starting materials: sole by-product is water

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Abstract

A high-yielding three-component reaction proceeds under mild, solvent-free conditions for access to a wide variety of fully-substituted propargylamines. Inexpensive copper(II) chloride catalyzes the coupling of equimolar amounts of amines, alkynes, and cyclohexanone such that the only by-product is one equivalent of water.

Graphical abstract: Copper(ii) catalysis provides cyclohexanone-derived propargylamines free of solvent or excess starting materials: sole by-product is water

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Publication details

The article was received on 10 May 2012, accepted on 26 Jun 2012 and first published on 18 Jul 2012


Article type: Communication
DOI: 10.1039/C2GC35713E
Green Chem., 2012,14, 2672-2676

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    Copper(II) catalysis provides cyclohexanone-derived propargylamines free of solvent or excess starting materials: sole by-product is water

    C. J. Pierce and C. H. Larsen, Green Chem., 2012, 14, 2672
    DOI: 10.1039/C2GC35713E

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