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Issue 1, 2012
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(−)-Secoisolariciresinol attenuates high-fat diet-induced obesity in C57BL/6 mice

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Abstract

Flaxseed lignan, secoisolariciresinol has been reported to possess health benefits. We previously synthesized each stereoisomer of secoisolariciresinol and found that (−)-secoisolariciresinol reduces lipid accumulation and induces adiponectin production in 3T3-L1 adipocytes. Here we show the effects of (−)-secoisolariciresinol on high-fat diet-induced obesity in C57BL/6 male mice. Oral administration of (−)-secoisolariciresinol for 28 consecutive days significantly suppressed the gain of body weight. Increased serum adiponectin level and decreased gene expression of fatty acid synthase and sterol regulatory element-binding protein-1c in liver, which are related to fatty acid synthesis, were observed in the mice orally administered with (−)-secoisolariciresinol. In addition, subcutaneous injection of (−)-secoisolariciresinol also significantly suppressed the gain of body weight. Serum leptin levels were significantly increased by treating with (−)-secoisolariciresinol or (−)-enterolactone. Subcutaneous injection of (−)-secoisolariciresinol, (−)-enterolactone, or (−)-enterodiol promoted gene expression of acyl-CoA oxidase, carnitine palmitoyl transferase-1, and peroxisome proliferator-activated receptor α, which are related to β-oxidation. Overall results suggest that (−)-secoisolariciresinol exerts a suppressive effect on the gain of body weight of mice fed a high-fat diet by inducing gene expression of adiponectin, resulting in the altered expression of various genes related to the synthesis and β-oxidation of fatty acids.

Graphical abstract: (−)-Secoisolariciresinol attenuates high-fat diet-induced obesity in C57BL/6 mice

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Publication details

The article was received on 19 Aug 2011, accepted on 08 Oct 2011 and first published on 27 Oct 2011


Article type: Paper
DOI: 10.1039/C1FO10166H
Food Funct., 2012,3, 76-82

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    (−)-Secoisolariciresinol attenuates high-fat diet-induced obesity in C57BL/6 mice

    S. Tominaga, K. Nishi, S. Nishimoto, K. Akiyama, S. Yamauchi and T. Sugahara, Food Funct., 2012, 3, 76
    DOI: 10.1039/C1FO10166H

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