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Issue 42, 2012
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A chiral probe for the acute phase proteins alpha-1-acid glycoprotein and alpha-1-antitrypsin based on europium luminescence

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Abstract

Reversible and selective binding of a dynamically racemic europium(III) complex to α1-acid glycoprotein and α1-antitrypsin is characterised by a significant change in the europium total emission spectral fingerprint and the switching on of a large circularly polarised luminescence (CPL) signal from the metal centre. Observation of an induced CD into the ligand chromophore in the presence of α1-AGP allows a structure for the protein-bound complex to be postulated. A direct determination of elevated α1-AGP levels in human serum was achieved by monitoring changes in the intensity ratio of Eu emission bands.

Graphical abstract: A chiral probe for the acute phase proteins alpha-1-acid glycoprotein and alpha-1-antitrypsin based on europium luminescence

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Supplementary files

Article information


Submitted
29 Nov 2011
Accepted
13 Feb 2012
First published
14 Feb 2012

Dalton Trans., 2012,41, 13154-13158
Article type
Paper

A chiral probe for the acute phase proteins alpha-1-acid glycoprotein and alpha-1-antitrypsin based on europium luminescence

R. Carr, L. Di Bari, S. Lo Piano, D. Parker, R. D. Peacock and J. M. Sanderson, Dalton Trans., 2012, 41, 13154
DOI: 10.1039/C2DT30143A

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