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Issue 16, 2012
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Synthesis and characterization of novel chiral NHC–palladium complexes and their application in copper-free Sonogashira reactions

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Abstract

A new series of chiral N-heterocyclic carbene (NHC) palladium complexes were synthesized from a relatively inexpensive amino acid, L-phenylalanine. All these compounds were fully characterized by 1H-NMR, 13C-NMR and elemental analysis. The X-ray molecular structures of two of the complexes were reported. The catalytic activity of the four palladium complexes was successfully tested in the Sonogashira reaction under copper free conditions in air. The palladium complex 3a provided good activity in the Sonogashira coupling reaction.

Graphical abstract: Synthesis and characterization of novel chiral NHC–palladium complexes and their application in copper-free Sonogashira reactions

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Supplementary files

Article information


Submitted
12 Dec 2011
Accepted
12 Feb 2012
First published
13 Feb 2012

Dalton Trans., 2012,41, 5020-5025
Article type
Paper

Synthesis and characterization of novel chiral NHC–palladium complexes and their application in copper-free Sonogashira reactions

L. Yang, P. Guan, P. He, Q. Chen, C. Cao, Y. Peng, Z. Shi, G. Pang and Y. Shi, Dalton Trans., 2012, 41, 5020 DOI: 10.1039/C2DT12391F

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