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Issue 21, 2012
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Interference of a new cyclometallated Pt compound with Cu binding to amyloid-β peptide

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Abstract

Coordination of a cyclometallated Pt(II) complex (1) to an amyloid-β peptide was probed by NMR and ESI-MS. Furthermore, EPR showed that binding of 1 to the Cu(II)-amyloid-β species resulted in a reshuffling of the Cu(II) coordination sphere, which was absent or lower for the sister non cyclometallated Pt(II) complexes.

Graphical abstract: Interference of a new cyclometallated Pt compound with Cu binding to amyloid-β peptide

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Publication details

The article was received on 14 Nov 2011, accepted on 06 Jan 2012 and first published on 03 Feb 2012


Article type: Communication
DOI: 10.1039/C2DT12177H
Dalton Trans., 2012,41, 6404-6407

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    Interference of a new cyclometallated Pt compound with Cu binding to amyloid-β peptide

    I. Sasaki, C. Bijani, S. Ladeira, V. Bourdon, P. Faller and C. Hureau, Dalton Trans., 2012, 41, 6404
    DOI: 10.1039/C2DT12177H

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