Jump to main content
Jump to site search

Issue 21, 2012
Previous Article Next Article

Polyanionic N-donor ligands as chelating agents in transition metal complexes: synthesis, structural characterization and antiviral properties against HIV

Author affiliations

Abstract

We describe here the synthesis and characterization of new sulfonated and carboxylated-containing N-donor ligands [Na4(edts)]·4H2O (2), [Na2(dmeddp)]·2H2O (3) and [Na4(edtp)]·H2O (4) (edts = ethylene-diamine- N,N,N′,N′-tetraethylenesulfonate ion; dmeddp = dimethyl-ethylene-diamine-N,N,N′,N′-tetra-3-propionate ion; edtp = ethylene-diamine-N,N,N′,N′-tetra-3-propionate ion) and their corresponding metal (Ni, Co, Cu and Zn) complexes. Mainly, UV-Vis and a computer aided analysis of the EPR spectra provided information on the geometry and structure of the complexes in solution. Some of the metal complexes inhibit HIV replication when treating both pre- and post-infected PBMC cells, and hustle the inhibitory effect compared to the metal salts alone.

Graphical abstract: Polyanionic N-donor ligands as chelating agents in transition metal complexes: synthesis, structural characterization and antiviral properties against HIV

Back to tab navigation

Publication details

The article was received on 21 Sep 2011, accepted on 21 Dec 2011 and first published on 07 Feb 2012


Article type: Paper
DOI: 10.1039/C2DT11793B
Dalton Trans., 2012,41, 6488-6499

  •   Request permissions

    Polyanionic N-donor ligands as chelating agents in transition metal complexes: synthesis, structural characterization and antiviral properties against HIV

    S. García-Gallego, J. S. Rodríguez, J. L. Jiménez, M. Cangiotti, M. F. Ottaviani, M. Á. Muñoz-Fernández, R. Gómez and F. J. de la Mata, Dalton Trans., 2012, 41, 6488
    DOI: 10.1039/C2DT11793B

Search articles by author

Spotlight

Advertisements