Jump to main content
Jump to site search

Issue 8, 2012
Previous Article Next Article

Dicarba-closo-dodecarborane-containing half-sandwich complexes of ruthenium, osmium, rhodium and iridium: biological relevance and synthetic strategies

Author affiliations

Abstract

This review describes how the incorporation of dicarba-closo-dodecarboranes into half-sandwich complexes of ruthenium, osmium, rhodium and iridium might lead to the development of a new class of compounds with applications in medicine. Such a combination not only has unexplored potential in traditional areas such as Boron Neutron Capture Therapy agents, but also as pharmacophores for the targeting of biologically important proteins and the development of targeted drugs. The synthetic pathways used for the syntheses of dicarba-closo-dodecarboranes-containing half-sandwich complexes of ruthenium, osmium, rhodium and iridium are also reviewed. Complexes with a wide variety of geometries and characteristics can be prepared. Examples of addition reactions on the metal centre, B–H activation, transmetalation reactions and/or direct formation of metal–metal bonds are discussed (103 references).

Graphical abstract: Dicarba-closo-dodecarborane-containing half-sandwich complexes of ruthenium, osmium, rhodium and iridium: biological relevance and synthetic strategies

Back to tab navigation

Publication details

The article was received on 07 Nov 2011 and first published on 03 Feb 2012


Article type: Critical Review
DOI: 10.1039/C2CS15300A
Chem. Soc. Rev., 2012,41, 3264-3279

  •   Request permissions

    Dicarba-closo-dodecarborane-containing half-sandwich complexes of ruthenium, osmium, rhodium and iridium: biological relevance and synthetic strategies

    N. P. E. Barry and P. J. Sadler, Chem. Soc. Rev., 2012, 41, 3264
    DOI: 10.1039/C2CS15300A

Search articles by author

Spotlight

Advertisements