Issue 7, 2012
From the journal:

Chemical Society Reviews

Polymeric multilayer capsules for drug delivery†

Stefaan De Koker,ab   Richard Hoogenboomc  and  Bruno G. De Geest*a  

* Corresponding authors

a Laboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
E-mail: br.degeest@ugent.be

b Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, 9052 Zwijnaarde, Belgium

c Supramolecular Chemistry Group, Department of Organic Chemistry, Ghent University, Krijgslaan 281 S4, 9000 Ghent, Belgium

Abstract

The advent of Layer-by-Layer (LbL) assembly to fabricate polymeric as well as hybrid multilayer thin films has opened exciting avenues for the design of multifunctional drug carriers with extreme control over their physico-chemical properties. These polymeric multilayer capsules (PMLC) are typically fabricated by sequential adsorption of polymers onto a spherical substrate with dimensions varying from 10 nm to several microns and larger. In this critical review, we give an overview of the recent advances in the field of PMLC with respect to drug delivery and point out how sophisticated capsule engineering can lead to well-defined drug carriers with unique properties (139 references).

Graphical abstract: Polymeric multilayer capsules for drug delivery

  • This article is part of the themed collection: Nanomedicine
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Article information

DOI
https://doi.org/10.1039/C2CS15296G
Article type
Critical Review
Submitted
04 Nov 2011
First published
26 Jan 2012

Chem. Soc. Rev., 2012,41, 2867-2884

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Polymeric multilayer capsules for drug delivery

S. De Koker, R. Hoogenboom and B. G. De Geest, Chem. Soc. Rev., 2012, 41, 2867 DOI: 10.1039/C2CS15296G

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