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Issue 9, 2012
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Halogen bonding in solution

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Halogen bonding is the electron density donation based weak interaction of halogens with Lewis bases. Its applicability for molecular recognition processes long remained unappreciated and has so far mostly been studied in silico and in solid state. As most physiological processes and chemical reactions take place in solution, investigations in solutions are of highest relevance for its use in the pharmaceutical and material scientific toolboxes. Following a short discussion of the phenomenon of halogen bonding, this tutorial review presents an overview of the methods hitherto applied for gaining an improved understanding of its behaviour in solutions and summarizes the gained knowledge in order to indicate the scope of the techniques and to facilitate exciting future developments.

Graphical abstract: Halogen bonding in solution

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Article information

30 Oct 2011
First published
14 Feb 2012

Chem. Soc. Rev., 2012,41, 3547-3557
Article type
Tutorial Review

Halogen bonding in solution

M. Erdélyi, Chem. Soc. Rev., 2012, 41, 3547
DOI: 10.1039/C2CS15292D

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