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Issue 6, 2012
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Low-loading asymmetric organocatalysis

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Abstract

Asymmetric organocatalysis is now recognized as the third pillar of asymmetric synthesis. Recent years have witnessed increasing interest towards the use of highly active and stereoselective organocatalysts. This critical review documents the advances in the development of chiral organocatalysts which are systematically used in ≤3 mol% loading in all the sub-areas of the field, namely aminocatalysis, Brønsted acids and bases, Lewis acids and bases, hydrogen bond-mediated catalysis, phase transfer and N-heterocyclic carbene catalyses (194 references).

Graphical abstract: Low-loading asymmetric organocatalysis

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Publication details

The article was received on 01 Aug 2011 and first published on 14 Dec 2011


Article type: Critical Review
DOI: 10.1039/C1CS15206H
Chem. Soc. Rev., 2012,41, 2406-2447

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    Low-loading asymmetric organocatalysis

    F. Giacalone, M. Gruttadauria, P. Agrigento and R. Noto, Chem. Soc. Rev., 2012, 41, 2406
    DOI: 10.1039/C1CS15206H

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