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Issue 2, 2012
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Misfolded proteins in Alzheimer's disease and type II diabetes

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This tutorial review presents descriptions of two amyloidogenic proteins, amyloid-β (Aβ) peptides and islet amyloid polypeptide (IAPP), whose misfolding propensities are implicated in Alzheimer's disease (AD) and type II diabetes, respectively. Protein misfolding diseases share similarities, as well as some unique protein-specific traits, that could contribute to the initiation and/or development of their associated conditions. Aβ and IAPP are representative amyloidoses and are used to highlight some of the primary considerations for studying misfolded proteins associated with human diseases in this review. Among these factors, their physiological formation, aggregation, interactions with metal ions and other protein partners, and toxicity are presented. Small molecules that target and modulate the metal–Aβ interaction and neurotoxicity are included to illustrate one of the current approaches for uncovering the complexities of protein misfolding at the molecular level.

Graphical abstract: Misfolded proteins in Alzheimer's disease and type II diabetes

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The article was received on 23 Apr 2011 and first published on 04 Aug 2011

Article type: Tutorial Review
DOI: 10.1039/C1CS15112F
Chem. Soc. Rev., 2012,41, 608-621

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    Misfolded proteins in Alzheimer's disease and type II diabetes

    A. S. DeToma, S. Salamekh, A. Ramamoorthy and M. H. Lim, Chem. Soc. Rev., 2012, 41, 608
    DOI: 10.1039/C1CS15112F

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