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Issue 43, 2012
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Comparing the interactions of DNA, polyamide (PNA) and polycarbamate nucleic acid (PCNA) oligomers with graphene oxide (GO)

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Abstract

The fluorescently labelled short octameric oligothymine sequences of DNA, PNA and PCNA were used in fluorescence quenching studies in conjunction with dispersed graphene oxide. The measurable restoration of their fluorescence by complementary oligodeoxyadenylate was compared. This is the first study aimed at replacing the natural DNA probes with synthetic DNA mimics that show excellent properties in terms of formation of very strong duplexes with cDNA in addition to their stability towards proteases and nucleases.

Graphical abstract: Comparing the interactions of DNA, polyamide (PNA) and polycarbamate nucleic acid (PCNA) oligomers with graphene oxide (GO)

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Article information


Submitted
08 Aug 2012
Accepted
20 Sep 2012
First published
21 Sep 2012

Phys. Chem. Chem. Phys., 2012,14, 15003-15006
Article type
Communication

Comparing the interactions of DNA, polyamide (PNA) and polycarbamate nucleic acid (PCNA) oligomers with graphene oxide (GO)

V. Kotikam, M. Fernandes and V. A. Kumar, Phys. Chem. Chem. Phys., 2012, 14, 15003
DOI: 10.1039/C2CP42770B

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