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Issue 16, 2012
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Mechanochemical synthesis of pyrazine:dicarboxylic acid cocrystals and a study of dissociation by quantitative phase analysis

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Abstract

Cocrystals of pyrazine with dicarboxylic acids were synthesised by mechanochemical methods. Crystal structure determination was performed by single crystal and powder X-ray diffraction (PXRD). The cocrystals consist of infinite 1D hydrogen-bonded chains exploiting the familiar pyridine-carboxylic acid synthon. The kinetics of dissociation of the pyrazine:phthalic acid cocrystal was studied at non-ambient conditions using PXRD and quantitative Rietveld phase analysis. We show that the dissociation process is both temperature and humidity dependent providing useful information about a possible dissociation mechanism.

Graphical abstract: Mechanochemical synthesis of pyrazine:dicarboxylic acid cocrystals and a study of dissociation by quantitative phase analysis

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Supplementary files

Article information


Submitted
26 Jan 2012
Accepted
14 May 2012
First published
15 May 2012

CrystEngComm, 2012,14, 5203-5208
Article type
Paper

Mechanochemical synthesis of pyrazine:dicarboxylic acid cocrystals and a study of dissociation by quantitative phase analysis

M. Arhangelskis, G. O. Lloyd and W. Jones, CrystEngComm, 2012, 14, 5203
DOI: 10.1039/C2CE25121C

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