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Issue 88, 2012
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Identifying the intermolecular hydrogen-bonding supramolecular synthons in an indomethacin–nicotinamide cocrystal by solid-state NMR

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Abstract

Two-dimensional 1H double-quantum and 14N–1H & 1H–13C heteronuclear magic-angle spinning (MAS) NMR spectra recorded at natural isotopic abundance identify specific intermolecular COOH⋯Narom and CHarom⋯O[double bond, length as m-dash]C hydrogen-bonding interactions in the solid-state structure of an indomethacin–nicotinamide cocrystal, thus additionally proving cocrystal formation.

Graphical abstract: Identifying the intermolecular hydrogen-bonding supramolecular synthons in an indomethacin–nicotinamide cocrystal by solid-state NMR

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Publication details

The article was received on 22 Aug 2012, accepted on 19 Sep 2012 and first published on 21 Sep 2012


Article type: Communication
DOI: 10.1039/C2CC36094B
Chem. Commun., 2012,48, 10844-10846

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    Identifying the intermolecular hydrogen-bonding supramolecular synthons in an indomethacin–nicotinamide cocrystal by solid-state NMR

    K. Maruyoshi, D. Iuga, O. N. Antzutkin, A. Alhalaweh, S. P. Velaga and S. P. Brown, Chem. Commun., 2012, 48, 10844
    DOI: 10.1039/C2CC36094B

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