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Issue 95, 2012
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Tailoring an alien ferredoxin to support native-like P450 monooxygenase activity

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Abstract

A ferredoxin associated with biological Fe–S cluster assembly has been remodelled to transfer electrons to a P450 enzyme and support substrate oxidation at 80% of the physiological ferredoxin activity, opening up the possibility of tailoring ferredoxins to reconstitute the activity of P450 enzymes for which the electron transfer partner proteins are not known.

Graphical abstract: Tailoring an alien ferredoxin to support native-like P450 monooxygenase activity

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Article information


Submitted
17 Aug 2012
Accepted
11 Oct 2012
First published
15 Oct 2012

Chem. Commun., 2012,48, 11692-11694
Article type
Communication

Tailoring an alien ferredoxin to support native-like P450 monooxygenase activity

S. G. Bell, J. H. C. McMillan, J. A. Yorke, E. Kavanagh, E. O. D. Johnson and L. Wong, Chem. Commun., 2012, 48, 11692
DOI: 10.1039/C2CC35968E

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