Issue 85, 2012
From the journal:

Chemical Communications

A covalently reactive group-modified peptide that specifically reacts with lysine16 in amyloid β†

Jing-Wen Ma,a   Lei Zhao,a   De-Sheng Zhao,a   Qian Liu,a   Chong Liu,a   Wei-Hui Wu,a   Yong-Xiang Chen,a   Yu-Fen Zhaoa  and  Yan-Mei Li*a  

* Corresponding authors

a Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China
E-mail: liym@mail.tsinghua.edu.cn
Fax: +86 10 6278 1695
Tel: +86 10 6279 6197

Abstract

Lys16 is present in the core region of the amyloid β (Aβ) self-assembly in Alzheimer's disease. Here we report that the P9-NCS peptide can covalently react with Lys16 and inhibit Aβ neurotoxic fibrillization. Moreover P9-NCS has high selectivity and it cannot react with amylin, insulin, fetal bovine serum, Q11 and MUC1 peptide.

Graphical abstract: A covalently reactive group-modified peptide that specifically reacts with lysine16 in amyloid β

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Article information

DOI
https://doi.org/10.1039/C2CC35178A
Article type
Communication
Submitted
19 Jul 2012
Accepted
02 Sep 2012
First published
03 Sep 2012

Chem. Commun., 2012,48, 10565-10567

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A covalently reactive group-modified peptide that specifically reacts with lysine16 in amyloid β

J. Ma, L. Zhao, D. Zhao, Q. Liu, C. Liu, W. Wu, Y. Chen, Y. Zhao and Y. Li, Chem. Commun., 2012, 48, 10565 DOI: 10.1039/C2CC35178A

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