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Issue 84, 2012
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Reengineered epipodophyllotoxin

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A variant structural skeleton of epipodophyllotoxin was synthesized and found to rival the natural cyclolignan in antiproliferative and microtubule destabilizing properties. This discovery leads to a new structural class of tubulin targeting agents.

Graphical abstract: Reengineered epipodophyllotoxin

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Publication details

The article was received on 14 Jul 2012, accepted on 29 Aug 2012 and first published on 17 Sep 2012

Article type: Communication
DOI: 10.1039/C2CC35044K
Chem. Commun., 2012,48, 10416-10418

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    Reengineered epipodophyllotoxin

    I. V. Magedov, N. M. Evdokimov, M. Karki, A. S. Peretti, D. T. Lima, L. V. Frolova, M. R. Reisenauer, A. E. Romero, P. Tongwa, A. Fonari, J. Altig, S. Rogelj, M. Yu. Antipin, C. B. Shuster and A. Kornienko, Chem. Commun., 2012, 48, 10416
    DOI: 10.1039/C2CC35044K

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