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Issue 77, 2012
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A Weinreb amide approach to the synthesis of trifluoromethylketones

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Abstract

A novel route to access trifluoromethylketones (TFMKs) from Weinreb amides is reported. This represents the first documented case of the Ruppert–Prakash reagent (TMS–CF3) reacting in a constructive manner with an amide and enables synthesis of TMFKs without risk of over-trifluoromethylation.

Graphical abstract: A Weinreb amide approach to the synthesis of trifluoromethylketones

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Supplementary files

Article information


Submitted
13 Jul 2012
Accepted
08 Aug 2012
First published
09 Aug 2012

Chem. Commun., 2012,48, 9610-9612
Article type
Communication

A Weinreb amide approach to the synthesis of trifluoromethylketones

D. M. Rudzinski, C. B. Kelly and N. E. Leadbeater, Chem. Commun., 2012, 48, 9610
DOI: 10.1039/C2CC35037H

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