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Issue 76, 2012
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Facile synthesis of colorimetric histone deacetylase substrates

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Abstract

Here we report a simple procedure for generating colorimetric histone deacetylase (HDAC) substrates by solid-phase peptide synthesis based on racemization-free couplings of amino acid chlorides. We demonstrate the applicability of these substrates in HDAC assays.

Graphical abstract: Facile synthesis of colorimetric histone deacetylase substrates

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Publication details

The article was received on 20 Jun 2012, accepted on 03 Aug 2012 and first published on 06 Aug 2012


Article type: Communication
DOI: 10.1039/C2CC34422J
Chem. Commun., 2012,48, 9525-9527

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    Facile synthesis of colorimetric histone deacetylase substrates

    A. Dose, J. O. Jost, A. C. Spieß, P. Henklein, M. Beyermann and D. Schwarzer, Chem. Commun., 2012, 48, 9525
    DOI: 10.1039/C2CC34422J

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