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Issue 67, 2012
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An excitation ratiometric Zn2+ sensor with mitochondria-targetability for monitoring of mitochondrial Zn2+ release upon different stimulations

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Abstract

A mitochondria-targeted fluorescent sensor (Mito-ST), constructed by integrating a sulfamoylbenzoxadiazole fluorophore with a phosphonium group, displays the specific Zn2+-induced hypsochromic shifts of both excitation (69 nm) and emission (35 nm) maxima. Its ratiometric Zn2+ imaging ability via dual excitation mode has been applied in MCF-7 cells to clarify the different behaviours of mitochondrial Zn2+ release stimulated by H2O2 and SNOC.

Graphical abstract: An excitation ratiometric Zn2+ sensor with mitochondria-targetability for monitoring of mitochondrial Zn2+ release upon different stimulations

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Publication details

The article was received on 21 May 2012, accepted on 02 Jul 2012 and first published on 02 Jul 2012


Article type: Communication
DOI: 10.1039/C2CC33648K
Chem. Commun., 2012,48, 8365-8367

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    An excitation ratiometric Zn2+ sensor with mitochondria-targetability for monitoring of mitochondrial Zn2+ release upon different stimulations

    Z. Liu, C. Zhang, Y. Chen, W. He and Z. Guo, Chem. Commun., 2012, 48, 8365
    DOI: 10.1039/C2CC33648K

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