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Issue 58, 2012
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Prediction of the stability of modified RNA duplexes based on deformability analysis: oligoribonucleotide derivatives modified with 2′-O-cyanoethyl-5-propynyl-2-thiouridine as a promising component

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Abstract

We describe a method to predict the stability of a modified RNA duplex. Ten unique modified RNA duplexes showed a linear relationship between the calculated and experimentally determined duplex stabilities.

Graphical abstract: Prediction of the stability of modified RNA duplexes based on deformability analysis: oligoribonucleotide derivatives modified with 2′-O-cyanoethyl-5-propynyl-2-thiouridine as a promising component

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Publication details

The article was received on 11 May 2012, accepted on 31 May 2012 and first published on 07 Jun 2012


Article type: Communication
DOI: 10.1039/C2CC33409G
Chem. Commun., 2012,48, 7313-7315

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    Prediction of the stability of modified RNA duplexes based on deformability analysis: oligoribonucleotide derivatives modified with 2′-O-cyanoethyl-5-propynyl-2-thiouridine as a promising component

    Y. Masaki, R. Miyasaka, K. Hirai, H. Tsunoda, A. Ohkubo, K. Seio and M. Sekine, Chem. Commun., 2012, 48, 7313
    DOI: 10.1039/C2CC33409G

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