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Issue 69, 2012
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Mapping protein-specific micro-environments in live cells by fluorescence lifetime imaging of a hybrid genetic-chemical molecular rotor tag

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Abstract

The micro-viscosity and molecular crowding experienced by specific proteins can regulate their dynamics and function within live cells. Taking advantage of the emerging TMP-tag technology, we present the design, synthesis and application of a hybrid genetic-chemical molecular rotor probe whose fluorescence lifetime can report protein-specific micro-environments in live cells.

Graphical abstract: Mapping protein-specific micro-environments in live cells by fluorescence lifetime imaging of a hybrid genetic-chemical molecular rotor tag

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Publication details

The article was received on 01 May 2012, accepted on 06 Jul 2012 and first published on 06 Jul 2012


Article type: Communication
DOI: 10.1039/C2CC33133K
Chem. Commun., 2012,48, 8694-8696

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    Mapping protein-specific micro-environments in live cells by fluorescence lifetime imaging of a hybrid genetic-chemical molecular rotor tag

    E. Gatzogiannis, Z. Chen, L. Wei, R. Wombacher, Y. Kao, G. Yefremov, V. W. Cornish and W. Min, Chem. Commun., 2012, 48, 8694
    DOI: 10.1039/C2CC33133K

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