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Issue 52, 2012
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Structural basis for oxygen sensing and signal transduction of the heme-based sensor protein Aer2 from Pseudomonas aeruginosa

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Abstract

The crystal structure of a truncated Aer2, a signal transducer protein from Pseudomonas aeruginosa, consisting of the heme-containing PAS and di-HAMP domains revealed that a distal tryptophan residue (Trp283) plays an important role in stabilizing the heme-bound O2 and intra-molecular signal transduction upon O2 binding.

Graphical abstract: Structural basis for oxygen sensing and signal transduction of the heme-based sensor protein Aer2 from Pseudomonas aeruginosa

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Publication details

The article was received on 06 Feb 2012, accepted on 08 May 2012 and first published on 09 May 2012


Article type: Communication
DOI: 10.1039/C2CC32549G
Chem. Commun., 2012,48, 6523-6525

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    Structural basis for oxygen sensing and signal transduction of the heme-based sensor protein Aer2 from Pseudomonas aeruginosa

    H. Sawai, H. Sugimoto, Y. Shiro, H. Ishikawa, Y. Mizutani and S. Aono, Chem. Commun., 2012, 48, 6523
    DOI: 10.1039/C2CC32549G

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