Issue 59, 2012

Imaging histamine in live basophils and macrophages with a fluorescent mesoionic acid fluoride

Abstract

Histamine is a biogenic amine with fundamental roles in circulatory and immune systems. We report a fluorescent small molecule (Histamine Blue) for imaging intracellular histamine in live basophils and macrophages. Histamine Blue is a fluorescent mesoionic acid fluoride that turns on upon reaction with histamine. The selective response of Histamine Blue enabled the visualization of intracellular histamine under different physiological conditions.

Graphical abstract: Imaging histamine in live basophils and macrophages with a fluorescent mesoionic acid fluoride

Supplementary files

Article information

Article type
Communication
Submitted
30 Mar 2012
Accepted
29 May 2012
First published
30 May 2012

Chem. Commun., 2012,48, 7401-7403

Imaging histamine in live basophils and macrophages with a fluorescent mesoionic acid fluoride

N. Kielland, M. Vendrell, R. Lavilla and Y. Chang, Chem. Commun., 2012, 48, 7401 DOI: 10.1039/C2CC32292G

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