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Issue 34, 2012
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Highly relaxing gadolinium based MRI contrast agents responsive to Mg2+ sensing

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Abstract

A Gd complex based on a polyphosphonated pyridyl ligand shows a very high stability in aqueous solution (log KEuL = 25.7), a high relaxivity (8.5 mM−1 s−1 at 25 °C and 20 MHz) and a marked and selective relaxivity enhancement (37%) in the presence of Mg2+, opening interesting perspectives for the design of cation responsive contrast agents.

Graphical abstract: Highly relaxing gadolinium based MRI contrast agents responsive to Mg2+ sensing

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Publication details

The article was received on 02 Feb 2012, accepted on 29 Feb 2012 and first published on 29 Feb 2012


Article type: Communication
DOI: 10.1039/C2CC30757J
Chem. Commun., 2012,48, 4085-4087

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    Highly relaxing gadolinium based MRI contrast agents responsive to Mg2+ sensing

    S. Abada, A. Lecointre, M. Elhabiri, D. Esteban-Gómez, C. Platas-Iglesias, G. Tallec, M. Mazzanti and L. J. Charbonnière, Chem. Commun., 2012, 48, 4085
    DOI: 10.1039/C2CC30757J

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