Issue 27, 2012
From the journal:

Chemical Communications

Expanding the regioselective enzymatic repertoire: oxidative mono-cleavage of dialkenes catalyzed by Trametes hirsuta†

Caroline E. Paul,a   Aashrita Rajagopalan,b   Iván Lavandera,a   Vicente Gotor-Fernández,a   Wolfgang Kroutil*b  and  Vicente Gotor*a  

* Corresponding authors

a Department of Organic and Inorganic Chemistry, University of Oviedo, Instituto de Biotecnología de Asturias, Calle Julián Clavería 8, 33006 Oviedo, Spain
E-mail: vgs@uniovi.es
Fax: +34 985103448
Tel: +34 985103448

b Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, Heinrichstrasse 28, 8010 Graz, Austria
E-mail: Wolfgang.Kroutil@uni-graz.at
Fax: +43 316 380 9840
Tel: +43 316 380 5350

Abstract

The first report of a biocatalytic regioselective oxidative mono-cleavage of dialkenes was successfully achieved employing a cell-free enzyme preparation from Trametes hirsuta at the expense of molecular oxygen. Selected reactions were performed on a preparative scale affording high to excellent conversions and chemoselectivities.

Graphical abstract: Expanding the regioselective enzymatic repertoire: oxidative mono-cleavage of dialkenes catalyzed by Trametes hirsuta

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Article information

DOI
https://doi.org/10.1039/C2CC17572J
Article type
Communication
Submitted
04 Dec 2011
Accepted
10 Feb 2012
First published
10 Feb 2012

Chem. Commun., 2012,48, 3303-3305

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Expanding the regioselective enzymatic repertoire: oxidative mono-cleavage of dialkenes catalyzed by Trametes hirsuta

C. E. Paul, A. Rajagopalan, I. Lavandera, V. Gotor-Fernández, W. Kroutil and V. Gotor, Chem. Commun., 2012, 48, 3303 DOI: 10.1039/C2CC17572J

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