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Issue 99, 2012
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Rhodium and copper-catalyzed asymmetric conjugate addition of alkenyl nucleophiles

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Abstract

Since the initial reports in the mid-90s, metal catalyzed asymmetric conjugate addition (ACA) reactions evolved as an important tool for the synthetic chemist. Most of the research efforts have been done in the field of rhodium and copper catalyzed ACA reactions employing aryl and alkyl nucleophiles. Despite the great synthetic value of the double bond, the addition of alkenyl nucleophiles remains insufficiently explored. In this account, an overview of the developments in the field of rhodium and copper catalyzed ACA reactions with organometallic alkenyl reagents (B, Mg, Al, Si, Zr, Sn) will be provided. The account is intended to give a comprehensive overview of all the existing methods. However, in many cases only selected examples are displayed in order to facilitate comparison of different ligands and methodologies.

Graphical abstract: Rhodium and copper-catalyzed asymmetric conjugate addition of alkenyl nucleophiles

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Article information


Submitted
27 Jun 2012
Accepted
02 Oct 2012
First published
03 Oct 2012

Chem. Commun., 2012,48, 12037-12049
Article type
Feature Article

Rhodium and copper-catalyzed asymmetric conjugate addition of alkenyl nucleophiles

D. Müller and A. Alexakis, Chem. Commun., 2012, 48, 12037
DOI: 10.1039/C2CC34607A

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