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Issue 68, 2012
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Live cell imaging of lysosomal pH changes with pH responsive ratiometric lanthanide probes

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Abstract

Europium and terbium complexes of two structurally related ligands have been evaluated as optical probes to monitor changes in lysosomal pH; calibration using ionophores and fluorescent probes allows monitoring of the time dependence of lysosomal pH change, examining the green/red intensity ratio from internalised Tb–Eu complexes.

Graphical abstract: Live cell imaging of lysosomal pH changes with pH responsive ratiometric lanthanide probes

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Supplementary files

Article information


Submitted
14 Jun 2012
Accepted
10 Jul 2012
First published
11 Jul 2012

Chem. Commun., 2012,48, 8520-8522
Article type
Communication

Live cell imaging of lysosomal pH changes with pH responsive ratiometric lanthanide probes

D. G. Smith, B. K. McMahon, R. Pal and D. Parker, Chem. Commun., 2012, 48, 8520
DOI: 10.1039/C2CC34267G

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