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Issue 77, 2012
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Hybridization and reaction-based fluorogenic nucleic acid probes

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Abstract

We developed fluorogenic probes, which are photoactivated in the presence of specific nucleic acid templates with the release of fluorescent dyes. This templated reaction can be used to target specific nucleic acids in complex mixtures. We further demonstrate that this reaction can be monitored by single-molecule fluorescence imaging.

Graphical abstract: Hybridization and reaction-based fluorogenic nucleic acid probes

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Supplementary files

Article information


Submitted
28 May 2012
Accepted
07 Aug 2012
First published
08 Aug 2012

Chem. Commun., 2012,48, 9664-9666
Article type
Communication

Hybridization and reaction-based fluorogenic nucleic acid probes

S. Dutta, B. Flottmann, M. Heilemann and A. Mokhir, Chem. Commun., 2012, 48, 9664
DOI: 10.1039/C2CC33827K

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