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Issue 61, 2012
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Signal-on electrochemical Y or junction probe detection of nucleic acid

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Abstract

A methylene-blue (MB)-labeled molecular beacon junction probe allows for a signal-on electrochemical detection of nucleic acids via target recycling using endonucleases. Electron transfer is reduced when the MB is intercalated in the stem of the molecular beacon, but then electron transfer from MB to a gold electrode is enhanced upon cleavage of the junction probe due to increased probability of MB approaching the electrode when attached to the more flexible ssDNA.

Graphical abstract: Signal-on electrochemical Y or junction probe detection of nucleic acid

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Supplementary files

Article information


Submitted
08 May 2012
Accepted
01 Jun 2012
First published
08 Jun 2012

Chem. Commun., 2012,48, 7580-7582
Article type
Communication

Signal-on electrochemical Y or junction probe detection of nucleic acid

Z. Shen, S. Nakayama, S. Semancik and H. O. Sintim, Chem. Commun., 2012, 48, 7580 DOI: 10.1039/C2CC33280A

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