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Issue 57, 2012
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Synthetic mammalian riboswitches based on guanine aptazyme

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Abstract

Allosteric hammerhead ribozymes (aptazymes) that are activated by guanine were used to control mammalian gene expression in cis and in trans. Coexpression of the two mechanistically distinct riboswitches resulted in an improved dynamic range of gene expression.

Graphical abstract: Synthetic mammalian riboswitches based on guanine aptazyme

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Supplementary files

Article information


Submitted
02 May 2012
Accepted
29 May 2012
First published
30 May 2012

Chem. Commun., 2012,48, 7215-7217
Article type
Communication

Synthetic mammalian riboswitches based on guanine aptazyme

Y. Nomura, D. Kumar and Y. Yokobayashi, Chem. Commun., 2012, 48, 7215
DOI: 10.1039/C2CC33140C

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