Jump to main content
Jump to site search

Issue 57, 2012
Previous Article Next Article

Beyond azide–alkyneclick reaction: easy access to 18F-labelled compounds vianitrile oxide cycloadditions

Author affiliations

Abstract

Radiofluorinated 4-fluorobenzonitrile oxide and N-hydroxy-4-fluorobenzimidoyl chloride rapidly react with different alkenes and alkynes under mild conditions. These cycloadditions are suitable for the preparation of low-molecular weight radiopharmaceuticals and, in a strain-promoted variant, can enable easy labelling of sensitive biopolymers.

Graphical abstract: Beyond azide–alkyne click reaction: easy access to 18F-labelled compounds via nitrile oxide cycloadditions

Back to tab navigation

Supplementary files

Publication details

The article was received on 22 Feb 2012, accepted on 17 Apr 2012 and first published on 17 Apr 2012


Article type: Communication
DOI: 10.1039/C2CC31335A
Chem. Commun., 2012,48, 7134-7136

  •   Request permissions

    Beyond azide–alkyne click reaction: easy access to 18F-labelled compounds via nitrile oxide cycloadditions

    B. D. Zlatopolskiy, R. Kandler, D. Kobus, F. M. Mottaghy and B. Neumaier, Chem. Commun., 2012, 48, 7134
    DOI: 10.1039/C2CC31335A

Search articles by author

Spotlight

Advertisements