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Issue 43, 2012
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Distinguishing between polymorphic forms of linezolid by solid-phase electronic and vibrational circular dichroism

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Abstract

For the first time two crystalline forms of the same compound (linezolid polymorphs) were investigated by means of the solid-phase ECD and VCD spectra. The ECD spectra show distinct differences and the band at 221 nm serves as a diagnostic one because it is present in form II but absent in form III. The VCD spectra strongly differ in the diagnostic carbonyl absorption range exhibiting two relatively strong bands of opposite signs.

Graphical abstract: Distinguishing between polymorphic forms of linezolid by solid-phase electronic and vibrational circular dichroism

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Publication details

The article was received on 17 Feb 2012, accepted on 28 Feb 2012 and first published on 29 Feb 2012


Article type: Communication
DOI: 10.1039/C2CC31207G
Chem. Commun., 2012,48, 5295-5297

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    Distinguishing between polymorphic forms of linezolid by solid-phase electronic and vibrational circular dichroism

    J. Frelek, M. Górecki, M. Łaszcz, A. Suszczyńska, E. Vass and W. J. Szczepek, Chem. Commun., 2012, 48, 5295
    DOI: 10.1039/C2CC31207G

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