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Issue 17, 2012
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Fluorescent dye-doped silicananoparticles: new tools for bioapplications

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Abstract

The need to decipher various biological events has led to the elucidation of the molecular mechanisms underlying a number of disease processes. Consequently, the detection and simultaneous monitoring of chemical interactions between biological targets has become indispensable in medical diagnosis, targeted therapeutics, and molecular biology. Multiplexed applications employing nanomaterials, which represent the integration of nanotechnology and biology, have changed the bioanalytical outlook and provided various promising tools. Among these nanomaterials, fluorescent dye-doped silica nanoparticles have demonstrated excellent potential for use in advanced bioanalysis to facilitate deeper understanding of biology and medicine at the molecular level. In particular, silica nanoparticles have been applied to diagnostics and therapeutic applications in cancer and gene/drug delivery. This feature article summarizes recent developments in the synthesis, biocompatibility, and bioapplications of fluorescent dye-doped silica nanoparticles.

Graphical abstract: Fluorescent dye-doped silica nanoparticles: new tools for bioapplications

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Article information


Submitted
11 Oct 2011
Accepted
14 Dec 2011
First published
14 Dec 2011

Chem. Commun., 2012,48, 2270-2282
Article type
Feature Article

Fluorescent dye-doped silica nanoparticles: new tools for bioapplications

S. W. Bae, W. Tan and J. Hong, Chem. Commun., 2012, 48, 2270 DOI: 10.1039/C2CC16306C

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