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Issue 6, 2012
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In situ nanochemical imaging of label-free drugs: a case study of antimalarials in Plasmodium falciparum-infected erythrocytes

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Abstract

We report here for the first time the in vitrolocalization of unlabeled antimalarial drugs with high spatial resolution. This strategy further enhances our understanding of the action mechanisms of antimalarial drugs. Our approach may be applied to a wide range of domains where quantitative chemical imaging of drugs at the sub-cellular level appears critical.

Graphical abstract: In situ nanochemical imaging of label-free drugs: a case study of antimalarials in Plasmodium falciparum-infected erythrocytes

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Supplementary files

Article information


Submitted
06 Oct 2011
Accepted
18 Nov 2011
First published
21 Nov 2011

Chem. Commun., 2012,48, 910-912
Article type
Communication

In situ nanochemical imaging of label-free drugs: a case study of antimalarials in Plasmodium falciparum-infected erythrocytes

F. Dubar, S. Bohic, C. Slomianny, J. Morin, P. Thomas, H. Kalamou, Y. Guérardel, P. Cloetens, J. Khalife and C. Biot, Chem. Commun., 2012, 48, 910
DOI: 10.1039/C1CC16211J

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